The Private Investment Construction (PIC) Framework is a four-year deal divided into a series of lots.
Winning contractors will work on new build and refurbishment jobs across the country funded by private money.
The framework has been launched by Yeovil District Hospital NHS Foundation Trust but can be used by other public bodies.
An OJEU notice stated: “It will provide the qualifying participants with a mechanism for the delivery of public sector infrastructure works, creating a quick, efficient and flexible vehicle for accessing high quality and experienced building contractors for the construction of projects developed using private funding.”
At least ten companies will be shortlisted for the deal which is divided into lots of contracts geographically and above and below £10m.
The framework is being managed by Prime Contractor Framework Management Co Limited.